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25th Asia Pacific Neonatology and Pediatric Congress

Tokyo, Japan

Said Moustafa M, Eldeib

NMC Health Care Group, Abu Dahbi- UAE

Title: Necrotizing Enterocolitis in a Preterm Infant Newborn & Role of Feeding …. An Update!


Biography: Said Moustafa M, Eldeib


It’s a clinical case presentation of a male Preterm infant Newborn (+31 wks) who was delivered in our  hospital  &  transferred  to  our  NICU  because  of  Prematurity,  VLBW  &  need  to  respiratory support. Baby shortly undergo Necrotizing Enterocolitis (NEC) on 5th day of life shortly after start of  expressed  milk  feeding  …!  Which  was  early  detected  by  use  of  Near  Infrared  Abdominal spectroscopy (NIRS).  Baby was  deteriorated  clinically in  a  couple  of  hours  &  undergo  intestinal perforation with peritonitis , So, Abdominal exploration surgery with intestinal resection & end – to end anastomosis was done urgently.

Baby improved gradually & early feedings was started & gradually increased up to full feedings with use of Human Fortified Milk (HMF) & probiotics , Prebiotics.

Findings:  The  Study  stated  the  evidence-based  Feeding  Strategies  guidelines  for  necrotizing enterocolitis (NEC)  among very low birth  weight infants  & Role of trophic feedings, Probiotics, Prebiotics & micronutrients in Prophylaxis, Prevention & Management of NEC.

Recommendations:  1)  -Prematurity  is  the  single  greatest  risk  factor  for  NEC  &  avoidance  of premature birth is the best way to prevent NEC. 2)-The role of feeding in the pathogenesis of NEC is uncertain, but it seems prudent to use breast milk (when available) and advance feedings slowly and cautiously. 3)-NEC is one of the leading causes of mortality, and the most common reason for emergent GI surgery in newborns. 4)-NEC remains a major unsolved medical challenge, for which no specific therapy exists, and its pathogenesis remains controversial. 5)-A better understanding of the  pathophysiology  will  offer  new  and  innovative  therapeutic  approaches,  and  future  studies should  be  focused  on  the  roles  of  the  epithelial  barrier,  innate  immunity,  and  microbiota  in  this disorder.  6)-Bioinformatics  modeling  is  a  new  emerging  strategy  aimed  at  understanding  the dynamics of various inflammatory markers and their application in early diagnosis and treatment.